Here’s another must watch great discussion with immunology professor Robert Clancy. This discussion provides an excellent summary of many of the things I’ve been writing about CORRECTLY for the past few years…and coincidentally recently summarized in a response comment to a Substack post, some DM’s and some tweets. So what follows below is an amalgam of those response comments, DM’s and tweets.
Anyone who uses the term “anti-vaxxer” as a pejorative is a simpleton. There are a wide array of vax types for a variety of viruses. Some of these vaccine platforms, esp for non zoonotic viruses, provide broad & durable immune responses. Others, incl mRNA C19 vaccines don’t. In general slow mutating non zoonotic/reverse zoonotic viruses with long incubation times lend themselves to more effective and durable vaccines. Fast mutating zoonotic/reverse zoonotic viruses with short incubation times don’t. Vaccines like attenuated and inactivated vaccines that use the whole virus with a lot of epitopes from various proteins of the virus typically provide broader less evasive immune responses than those vaccines that use only a few epitopes from one of the proteins of a virus.
So, in other words, viruses and their corresponding vaccines vary considerably. Thus each vaccine has to be looked at individually on its own merits. Thus you can be for, against or ambivalent to different vaccines rather than all for or all against.
Regardless, any form of herd immunity depends on the durability and breadth of the immune response. In regards to the breadth of that immune response, a naturally occurring infection will give a much broader IgA/IgG mucosal/humoral/cellular immune response than a spike specific vaccine with only a few epitopes from the S protein. A natural infection give B cells and T cell responses to a wide array of viral proteins (N, M, E and S proteins) making it much harder for variants to evolve and evade B and T cells. With current mRNA vaccine, using only a few epitopes from the RBD & NTD of the S proteins was really stupid since this is the portion of this fast mutating single strand RNA virus that mutates the most. Prior attempts at making vaccines for corona viruses have been an absolute failure. These attempts have caused ADE or antibody enhancement which means the antibodies provoked by the vaccines instead of neutralizing viruses enhanced the ability of viruses to cause infections.
So since the mRNA (and viral vector) vaccines provide little to no lasting secretory mucosal IgA immunity, they allow people to get infected , the virus to replicate, and people to transmit to other people. Viral replication in vaxxed people allows for random mutations or worse recombinations that eventually lead to new variants that evade the neutralizing antibodies provoked by the spike antigens. Thus new updated versions of these vaccines just become a game of whack-a-mole causing the virus to mutate even further.I explained this in more detail in these blogs I wrote in 2021:
–From 2021/10/07: a-smarter-anti-viral-and-vaccine-strategy
–From 2021/12/05: why-vaccine-failure-is-a-great-business-model-for-vaccine-manufacturers
What’s kind of interesting is that Omicron variants to a certain degree have functioned like attenuated vaccines. Though there are people that still won’t develop IgA secretory immunity from natural infection due to selective IgA deficiency or SIgAD. I write about that here:
–From 2021/10/18: known-and-unknown-risk-factors
And then of course, there’s the whole new issue with the shift from IgG3 Nab’s (neutralizing antibodies) to IgG4 tolerant antibodies that many others have written about based on two recent peer reviewed studies that have been published. This has actually led to a lot of viral replication in vaccinated individuals due to protracted illnesses. Same problem has been occurring with Paxlovid use. Vaxxed people have had their immune systems compromised. A while back I discussed the problem of mutations in this old blog about immune compromised people leading to more mutations:
-From 2021/09/29: immune-comprised-suppressed-more-likely-source-of-mutations
So these vaxxed people in which this shift occurs essentially become petri dishes for new variants including recombinant variants where people are infected simultaneously with 2 variants that exchange genetic material to form a new variant. That’s what happened with XBB which has now morphed into XBB.1.5 in the Northeast that’s heavily vaxxed.
And yes, Gert was correct especially with these vaxxes that used the portion of a single strand RNA virus that mutates the most and a lot, the RBD of the spike, as it’s antigen with just a few epitopes. Conceptually it’s just really really really dumb.
So, in other words, I’m just “anti” really REALLY dumb vaccines.
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beyondspin 